Intelligence of school children: Los Angeles as a case study 1922-1932

In an effort to construct the most advanced school system in the nation, Los Angeles school administrators and educators initiated a new scientific method of group intelligence testing. Almost immediately educators discovered serious limitations with the process and resisted its exclusive use. This study examines the reception of this new technology in Los Angeles between 1922 and 1932. Many historians have seen those associated with I.Q. measuring as bulwarks supporting the hegemony of Anglo-Saxon upper-middle class society. While their criticism has brought some non-equitable aspects of twentieth-century public education to surface, it has not led to our understanding of how educators interpreted the tests. An analysis of the sources, including reports published in the Department of Psychology and Education Research Bulletin of the Los Angeles City Schools, the Teachers' and Principals' School Journal, and the Minute~ of the Board of Education, provides insight into how Los Angeles educators viewed standardized testing

A randomised controlled trial of a digital intervention (Renewed) to support symptom management, wellbeing and quality of life in cancer survivors

Background: Many cancer survivors following primary treatment have prolonged poor quality of life.Aim: To determine the effectiveness of a bespoke digital intervention to support cancer survivors.Design: Pragmatic parallel open randomised trial.Setting: UK general practices.Methods: People having finished primary treatment (&lt;= 10 years previously) for colo-rectal, breast or prostate cancers, with European-Organization-for-Research-and-Treatment-of-Cancer QLQ-C30 score &lt;85, were randomised by online software to: 1) detailed ‘generic’ digital NHS support (‘LiveWell’;n=906), 2) a bespoke complex digital intervention (‘Renewed’;n=903) addressing symptom management, physical activity, diet, weight loss, distress, or 3) ‘Renewed-with-support’ (n=903): ‘Renewed’ with additional brief email and telephone support. Results: Mixed linear regression provided estimates of the differences between each intervention group and generic advice: at 6 months (primary time point: n’s respectively 806;749;705) all groups improved, with no significant between-group differences for EORTC QLQ-C30, but global health improved more in both intervention groups. By 12 months there were: small improvements in EORTC QLQ-C30 for Renewed-with-support (versus generic advice: 1.42, 95% CIs 0.33-2.51); both groups improved global health (12 months: renewed: 3.06, 1.39-4.74; renewed-with-support: 2.78, 1.08-4.48), dyspnoea, constipation, and enablement, and lower NHS costs (generic advice £265: in comparison respectively £141 (153-128) and £77 (90-65) lower); and for Renewed-with-support improvement in several other symptom subscales. No harms were identified.Conclusion: Cancer survivors quality of life improved with detailed generic online support. Robustly developed bespoke digital support provides limited additional short term benefit, but additional longer term improvement in global healthenablement and symptom management, with substantially lower NHS costs.<br/

Immunological Mechanisms Mediating Hantavirus Persistence in Rodent Reservoirs

Hantaviruses, similar to several emerging zoonotic viruses, persistently infect their natural reservoir hosts, without causing overt signs of disease. Spillover to incidental human hosts results in morbidity and mortality mediated by excessive proinflammatory and cellular immune responses. The mechanisms mediating the persistence of hantaviruses and the absence of clinical symptoms in rodent reservoirs are only starting to be uncovered. Recent studies indicate that during hantavirus infection, proinflammatory and antiviral responses are reduced and regulatory responses are elevated at sites of increased virus replication in rodents. The recent discovery of structural and non-structural proteins that suppress type I interferon responses in humans suggests that immune responses in rodent hosts could be mediated directly by the virus. Alternatively, several host factors, including sex steroids, glucocorticoids, and genetic factors, are reported to alter host susceptibility and may contribute to persistence of hantaviruses in rodents. Humans and reservoir hosts differ in infection outcomes and in immune responses to hantavirus infection; thus, understanding the mechanisms mediating viral persistence and the absence of disease in rodents may provide insight into the prevention and treatment of disease in humans. Consideration of the coevolutionary mechanisms mediating hantaviral persistence and rodent host survival is providing insight into the mechanisms by which zoonotic viruses have remained in the environment for millions of years and continue to be transmitted to humans

A randomised controlled trial of a digital intervention (renewed) to support symptom management, wellbeing and quality of life in cancer survivors

Background: Many cancer survivors following primary treatment have prolonged poor quality of life. Aim: To determine the effectiveness of a bespoke digital intervention to support cancer survivors. Design: Pragmatic parallel open randomised trial. Setting: UK general practices. Methods: People having finished primary treatment (<= 10 years previously) for colo-rectal, breast or prostate cancers, with European-Organization-for-Research-and-Treatment-of-Cancer QLQ-C30 score <85, were randomised by online software to: 1)detailed ‘generic’ digital NHS support (‘LiveWell’;n=906), 2) a bespoke complex digital intervention (‘Renewed’;n=903) addressing symptom management, physical activity, diet, weight loss, distress, or 3) ‘Renewed-with-support’ (n=903): ‘Renewed’ with additional brief email and telephone support. Results: Mixed linear regression provided estimates of the differences between each intervention group and generic advice: at 6 months (primary time point: n’s respectively 806;749;705) all groups improved, with no significant between-group differences for EORTC QLQ-C30, but global health improved more in both intervention groups. By 12 months there were: small improvements in EORTC QLQ-C30 for Renewed-with-support (versus generic advice: 1.42, 95% CIs 0.33-2.51); both groups improved global health (12 months: renewed: 3.06, 1.39-4.74; renewed-with-support: 2.78, 1.08-4.48), dyspnoea, constipation, and enablement, and lower NHS costs (generic advice £265: in comparison respectively £141 (153-128) and £77 (90-65) lower); and for Renewed-with-support improvement in several other symptom subscales. No harms were identified. Conclusion: Cancer survivors quality of life improved with detailed generic online support. Robustly developed bespoke digital support provides limited additional short term benefit, but additional longer term improvement in global health enablement and symptom management, with substantially lower NHS costs

Estimating Bowhead Whale, Balaena mysticetus, Population Size and Rate of Increase from the 1993 Census

Estimating the population size and rate of increase of bowhead whales, Balaena mysticetus, is important because bowheads were the first species of great whale for which commercial whaling stopped and so their status indicates the recovery prospects of other great whales, and also because this information is used by the International Whaling Commission (IWC) to set the aboriginal subsistence whaling quota for Alaskan Eskimos. We describe the 1993 visual and acoustic census off Point Barrow, Alaska, which provides the best data available for estimating these quantities. We outline the definitive version of two statistical methods for estimating the population, the generalized removal method and the Bayes empirical Bayes method. The two methods give results that are close. The estimate of bowhead population size most recently accepted by the IWC Scientific Committee, 8200 with 95% estimation interval from 7200 to 9400, is based on the Bayes empirical Bayes posterior distribution presente..

‘What's coming up in the exam?’ A survey of teachers and the delivery of a gender-balanced curriculum

This articles reports on the findings of a study carried out in 2003-2004 which examined gender perspectives in the delivery and assessment of junior cycle history. The study was a collaborative effort between the School of Education and Lifelong Learning, University College Dublin, and the Centre for Gender and Women’s Studies, Trinity College Dublin. Commissioned by the Gender Equality Unit of the Department of Education and Science, the principal aim of the study was to examine how men and women are represented in the junior cycle history syllabus. The principal focus of this article is to report on a key aspect of the overall research study*/namely, the gendered nature of examination questions at junior cycle history and teachers’ beliefs in relation to gender equality in the classroom. Central to the study was a survey of the views of practising (n/249) and trainee history teachers (n/46). Key findings included the under-representation of females in the historical narrative and in the state examinations in junior cycle history and the frustration of a significant number of teachers at the lack of gender balance in available teaching materials

Inference from a Deterministic Population Dynamics Model for Bowhead Whales

We consider the problem of inference about a quantity of interest given different sources of information linked by a deterministic population dynamics model. Our approach consists of translating all the available information into a joint pre-model distribution on all the model inputs and outputs, and then restricting this to the submanifold defined by the model to obtain the joint post-model distribution. Marginalizing this yields inference, conditional on the model, about quantities of interest which can be functions of model inputs, model outputs, or both. Samples from the postmodel distribution are obtained by importance sampling and Rubin&apos;s SIR algorithm. The framework includes as a special case the situation where the pre-model information about the outputs consists of measurements with error; this reduces to standard Bayesian inference. The results are in the form of a sample from the post-model distribution and so can be examined using the full range of exploratory data analysis..